Alzheimer's Research & Therapy


Editors-in-Chief

  • Douglas Galasko, University of California, San Diego
  • Todd Golde, University of Florida
  • Gordon Wilcock, University of Oxford

Articles

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  • Proteases associated with neuronal degeneration

    Matrix metalloproteinases are elevated in patients with Alzheimer’s disease (AD) and might be associated with early pathogenesis of AD in individuals who have not developed overt cognitive dysfunction.

    Alzheimer's Research & Therapy 2010, 2:20
  • Linking vascular health and dementia

    Stroke and the APOE epsilon4 allele are strongly associated with dementia, and antihypertensive medications may inform the development of more effective interventions and treatments.

    Alzheimer's Research & Therapy 2010, 2:19
  • Genotype influences Alzheimer’s interactions

    Variations in the ApoE genotype may affect the rate of disease progression and response to therapy in Alzheimer’s disease, suggesting it should be included as a covariate for future trials.

    Alzheimer's Research & Therapy 2010, 2:15
  • Exploring cell division in Alzheimer’s disease

    Cell cycle events in Alzheimer’s disease and other late-onset neurodegenerative diseases are not fully understood, but elucidating these complex relationships may pave the way to developing new therapeutic interventions.

    Alzheimer's Research & Therapy 2010, 2:13
  • Dementia frequency increases in the oldest old

    The implications of a study suggesting an exponential rise in dementia in persons 90 years and older are discussed and compared to other studies reporting a slowing incidence.

    Alzheimer's Research & Therapy 2010, 2:9
  • Inflammatory biomarker use in risk-stratification

    Tan and Seshadri consider evidence linking inflammation to Alzheimer’s disease risk, discussing the growing body of evidence that suggests inflammatory biomarkers could be used to risk-stratify people for preventative/therapeutic interventions.

    Alzheimer's Research & Therapy 2010, 2:6
  • Lessons learned from failed Alzheimer’s trials

    Prins and colleagues discuss the negative results of the recent bapineuzumab and tarenflurbil trials, the lessons learnt from them and comment on the potential implications for future novel therapeutics.

    Alzheimer's Research & Therapy 2010, 2:5
  • Pinpointing Alzheimer’s disease development mechanisms

    Williams comments on a recent study implicating inflammation and innate immunity in Alzheimer’s disease development, discussing these results in the context of recent genetic studies on the disease.

    Alzheimer's Research & Therapy 2010, 2:4

Aims & scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access research articles of outstanding quality. Alzheimer's Research & Therapy publishes basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. Although the primary focus is Alzheimer's dementia, the scope will encompass translational research into other neurodegenerative diseases.

Latest issue

Alzheimer's Research & Therapy Volume 2 Issue 3

The complete issue of Alzheimer's Research & Therapy Volume 2 Issue 3 is now available.

Latest review

All reviews, commentaries and reports published in Alzheimer's Research & Therapy are free to read. See below for the latest free review.

Genetics of Alzheimer disease in the pre- and post-GWAS era 

Nilüfer Ertekin-Taner

Alzheimer's Research & Therapy 2010, 2:3

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Indexed by

  • PubMed
  • PubMed Central
  • Google Scholar

ISSN: 1758-9193