Editors-in-Chief

  • Douglas R Galasko, University of California, San Diego
  • Todd E Golde, University of Florida
  • Philip Scheltens, VU University Medical Center

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Affiliated to Alzheimer's Disease International (ADI), London, United Kingdom

Alzheimer's Disease International is the international federation of national Alzheimer organisations and global voice for dementia, leading and unifying the dementia community to provide global solutions to a global epidemic.

Articles

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  • Aging and Alzheimer’s Disease

    Villemagne & colleagues discuss the Alzheimer’s Disease Neuroimaging Initiative, which represents a great opportunity to establish standards for the early diagnosis of Alzheimer’s disease, in a global effort to increase understanding of the pathophysiology of Alzheimer’s.

    Alzheimer's Research & Therapy 2014, 6:62
  • Cognitive testing in pathological aging and dementia

    Wesnes reviews the attributes of automated and non-automated cognitive assessments and suggests that the choice of assessment type should depend on the criteria relevant to the clinical trial in question.

    Alzheimer's Research & Therapy 2014, 6:58
  • The role of charities in Lewy body dementia

    The US Lewy Body Dementia Association and the UK Lewy Body Society discuss how charities can significantly reduce the burden that Lewy body dementia has on families and society, and are an additional resource to clinical care.

    Alzheimer's Research & Therapy 2014, 6:59
  • Targeting small vessel disease in AD

    Examination of subcortical hyperintensities revealed signs of small vessel disease, which may be differentially associated with specific cognitive functions and have potential clinical relevance as targets for treatment in Alzheimer’s disease (AD).

    Alzheimer's Research & Therapy 2014, 6:49
  • A novel target for tau immunotherapy

    Monoclonal antibody DC8E8 disables a novel target on tau protein essential for its pathological function both in vitro and in vivo, and is a suitable candidate molecule for Alzheimer's disease immunotherapy.

    Alzheimer's Research & Therapy 2014, 6:45
  • A novel vaccine for tau immunotherapy

    Active vaccine AADvac1 validates the novel tau target revealed by monoclonal antibody DC8E8 by reducing Alzheimer's disease-type tau hyperphosphorylation by 95% in transgenic rats, and has now entered phase I clinical trials.

    Alzheimer's Research & Therapy 2014, 6:44
  • Is MRI a suitable imaging biomarker for AD?

    Jeromin and colleagues discuss the use of magnetic resonance imaging (MRI) as a neuroimaging approach in the development of novel treatments for Alzheimer's disease (AD), including its role as a biomarker in clinical trials.

    Alzheimer's Research & Therapy 2014, 6:51
  • Protective effect of galantamine on brain atrophy rate

    Acetylcholinesterase inhibitor galantamine lowered the rate of whole brain atrophy, but not hippocampal atrophy, in mild cognitive impairment patients that carried the ε4 allele of apolipoprotein E only.

    Alzheimer's Research & Therapy 2014, 6:47

Latest review

The following review has recently become free to access:

Review Highly Accessed

Evidence for impaired amyloid β clearance in Alzheimer's disease

Kristin R Wildsmith, Monica Holley, Julie C Savage, Rebecca Skerrett, Gary E Landreth

Alzheimer's Research & Therapy 2013, 5:33 (12 July 2013)

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Aims & scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports. Although the primary focus is Alzheimer's dementia, the scope encompasses translational research into other neurodegenerative diseases.

Latest issue

Alzheimer's Research & Therapy Volume 6 Issue 3

The complete issue of Alzheimer's Research & Therapy Volume 6 Issue 3 is now available.

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Multimedia

The evolving field of traumatic brain injury

What do we currently know about chronic traumatic encephalopathy (CTE) and what are the most important questions in the field? Listen to a free podcast discussing this and more, as part of our special series on Traumatic Brain Injury.

Searching for biomarkers

As part of our special series on Peripheral Biomarkers, listen to a free podcast by Douglas Galasko about the advances and current issues in the search to identify blood biomarkers for Alzheimer's disease.

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ISSN: 1758-9193