Alzheimer's Research & Therapy


Editors-in-Chief

  • Douglas R Galasko, University of California, San Diego
  • Todd E Golde, University of Florida
  • Gordon K Wilcock, University of Oxford

Articles

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  • AD research highlights 2011-2012

    In their editorial, Editors-in-Chief Douglas Galasko, Todd Golde and Gordon Wilcock highlight several of the major translational research advances in Alzheimer's disease (AD) that have occurred over the past year.

    Alzheimer's Research & Therapy 2012, 4:14
  • Survival in an AD cohort

    Multiple factors influence survival in a large Alzheimer's disease (AD) cohort and the rate of cognitive decline at the initial patient visit is an important mortality predictor.

    Alzheimer's Research & Therapy 2012, 4:16
  • Deep brain stimulation in PD

    Jerrold Vitek comments on a recent research article addressing how long the benefits of deep brain stimulation for the treatment of Parkinson's disease (PD) can be sustained.

    Alzheimer's Research & Therapy 2012, 4:13
  • β-amyloid and α-synuclein interaction

    Marsh and Blurton-Jones review evidence suggesting β-amyloid (Aβ) and α-synuclein (α-syn) interact synergistically to enhance aggregation and accelerate cognitive decline, and propose potential mechanistic links between Aβ and α-syn pathologies.

    Alzheimer's Research & Therapy 2012, 4:11
  • LRP1 in amyloid deposition

    Reduction in levels of low-density lipoprotein receptor-related protein (LRP1) in an in vivo mouse model failed to observe a reduction in amyloidosis, questioning its significance as a potential therapeutic target for Alzheimer's disease.

    Alzheimer's Research & Therapy 2012, 4:12
  • APP proteolytic system interactions

    Hunter and Brayne build a map, modelling relationships between the amyloid precursor protein (APP) and its proteolytic fragments with other neuronal systems and discussing alternative perspectives for its role in Alzheimer's disease progression.

    Alzheimer's Research & Therapy 2012, 4:10
  • FAD: from genotype to phenotype

    The molecular consequences of amyloid precursor protein and presenilin gene mutations in familial Alzheimer's disease (FAD) are examined by Weggen and Beher; in view of potential therapeutic treatments directed at amyloid-beta peptides.

    Alzheimer's Research & Therapy 2012, 4:9
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Amyloid Imaging

Alzheimer's Research and Therapy Chromosome 9

Aims & scope

Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports. Although the primary focus is Alzheimer's dementia, the scope encompasses translational research into other neurodegenerative diseases.

Latest issue

Alzheimer's Research & Therapy Volume 4 Issue 2

The complete issue of Alzheimer's Research & Therapy Volume 4 Issue 2 is now available.

Latest free review

The following review has recently become free to access:

PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer's disease 

Michael J Pontecorvo, Mark A Mintun

Alzheimer's Research & Therapy 2011, 2:3:11 (29 March 2011)

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ISSN: 1758-9193