- Douglas R Galasko, University of California, San Diego
- Todd E Golde, University of Florida
- Philip Scheltens, VU University Medical Center
Affiliated to Alzheimer's Disease International (ADI), London, United Kingdom
Alzheimer's Disease International is the international federation of national Alzheimer organisations and global voice for dementia, leading and unifying the dementia community to provide global solutions to a global epidemic.
Siddique and colleagues review the ubiquitin-proteasome or autophagy pathways whose dysfunction might contribute to the pathology of various neurodegenerative diseases, discussing how induction of these pathways may be a therapeutic strategy.
A care coordination programme between community and health organisations for patients with Alzheimer's disease and their carers resulted in improvements in psychosocial function of people with dementia.
Histone deacetylase 6 (HDAC6) inhibition by tubastatin A improved memory and reduced total tau levels in a mouse model of tau deposition; supporting HDAC6 inhibitors as novel therapeutic agents against tau pathology.
Tau imaging agent 18F-THK523 selectively binds to paired helical filament-tau in Alzheimer's disease (AD) brains, but does not bind to tau-lesions in non-AD tauopathies or alpha-synuclein in Parkinson's disease brains.
Lin and Shenton review the advanced neuroimaging methods used to investigate repetitive brain trauma, which may lead to early diagnosis of individuals at risk of chronic traumatic encephalopathy, such as athletes and soldiers.
Strittmatter and colleagues review the putative signalling pathway of amyloid-beta and discuss evidence that implicates tyrosine kinase Fyn in the pathogenesis of Alzheimer's disease, through its interaction with both amyloid-beta and tau.
Winblad and colleagues review the active immunotherapy options currently in development, including the benefits and challenges associated with this approach, as part of a special series on Immunotherapy in Alzheimer’s disease.
Consecutive transfers of cerebrospinal fluid between tubes decreased concentrations of amyloid-beta (Aβ) peptides by 25% and altered biomarker ratios enough to mislead diagnosis, however use of Tween 20 mitigated this effect.
Latest free review
The following review has recently become free to access:
Nicole J Ridley, Brian Draper, Adrienne WithallAlzheimer's Research & Therapy 2013, 5:3 (25 January 2013)
News from Alzforum
From the blog
Aims & scope
Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. An international peer-reviewed journal, it publishes open access basic research with a translational focus, as well as clinical trials, research into drug discovery and development, and epidemiologic studies. The journal also provides reviews, viewpoints, commentaries, debates and reports. Although the primary focus is Alzheimer's dementia, the scope encompasses translational research into other neurodegenerative diseases.
The evolving field of traumatic brain injury
What do we currently know about chronic traumatic encephalopathy (CTE) and what are the most important questions in the field? Listen to a free podcast discussing this and more, as part of our special series on Traumatic Brain Injury.
Searching for biomarkers
As part of our special series on Peripheral Biomarkers, listen to a free podcast by Douglas Galasko about the advances and current issues in the search to identify blood biomarkers for Alzheimer's disease.