Table 3

Late-onset Alzheimer disease genome-wide association study: estimated population attributable risks of the top variants.

Non-ApoE hits (paper)

Non-ApoE hits (AlzGene meta-analysis)

ApoE-related hits

Reference

Best gene(s)

Best SNP(s)

MAF

OR

PAR

MAF

OR

PAR

Best gene(s)

Best SNP(s)

MAF

OR

PAR

Grupe et al. [50]

GALP

rs3745833

0.35

1.2

6.5%

0.35

1.13

4.4%

TOMM40

rs157581

0.15

2.73

20.6%

Coon et al. [51]

-

-

-

-

-

-

-

-

APOC1

rs4420638

0.18

4.01

35.1%

Reiman et al. [52]

GAB2

rs2373115

0.81

1.66

34.8%

0.82

1.22

15.3%

-

-

-

-

-

Li et al. [53]

GOLPH2

rs7019241

0.13

0.69

28.1%

-

-

-

APOC1

rs4420638

0.18

-

-

Abraham et al. [54]

LRAT

rs201825

0.45

1.3

11.9%

-

-

-

-

-

-

-

-

Bertram et al. [55]

chr14q31.2

rs11159647

0.48

1.4

16.0%

-

-

-

APOC1

rs4420638

0.18

-

-

Beecham et al. [56]

12q13

rs11610206

-

-

-

-

-

-

-

-

-

-

-

Feulner et al. [57]

LMNA

rs915179

0.35

-

-

-

-

-

TOMM40

rs157580 and rs2075650

0.4-0.14

-

-

Poduslo et al. [58]

TRPC4AP

rs6087664

-

-

-

-

-

-

-

-

-

-

-

Carrasquillo et al. [59]

PCDH11X

rs2573905

0.46

1.29

11.8%

-

-

-

TOMM40

rs2075650

0.13

3.29

22.9%

Harold et al. [60]

CLU

rs11136000

0.40

0.86

8.9%

0.6

0.85 (CLU)

9.6%

TOMM40

rs2075650

0.15

2.53

18.7%

PICALM

rs3851179

0.37

0.86

9.3%

0.36

0.88 (PICALM)

8.0%

Lambert et al. [61]

CLU

rs11136000

0.38

0.86

9.2%

0.6

0.85 (CLU)

9.6%

-

-

-

-

-

CR1

rs6656401

0.19

1.21

3.8%

0.18

1.19 (CR1)

3.3%

The minor allele frequencies (MAFs), odds ratios (ORs), and population attributable risks (PARs) of the best single-nucleotide polymorphisms (SNPs) in the top gene(s) from the 11 late-onset Alzheimer disease genome-wide association studies are shown, where available from the original publications. MAFs of the rs157581 and rs4420638 SNPs were not shown in the original publications and were obtained from the dbSNP database for subjects of European origin. The formula used to calculate PAR was F(OR - 1)/(F(OR - 1) + 1), where F = frequency of the risk allele and OR = odds ratio of the risk allele. Where available, the MAFs, ORs, and PARs emerging from meta-analyses in the AlzGene website are shown for the non-APOE results.

Ertekin-Taner Alzheimer's Research & Therapy 2010 2:3   doi:10.1186/alzrt26