Alzheimer's Research & Therapy | Volume 2 Issue 4

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	Volume 2 Issue 4
	Comment
	Commentary Advances in quantitative magnetic resonance imaging-based biomarkers for Alzheimer disease Bradford C Dickerson Alzheimers Res Ther 2010, 2:21 (6 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Advances in data acquisition and image-processing algorithms are helping us to measure brain changes in Alzheimer’s disease, but many challenges remain in translating this to the clinic.
	Viewpoint The role of animal models in advancing amyloid-beta immunotherapy to the clinic Dora Games, Peter Seubert Alzheimers Res Ther 2010, 2:22 (29 July 2010) Abstract \| Full text \| PDF \| PubMed
	Review
	Review The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation? Kerensa Broersen, Frederic Rousseau, Joost Schymkowitz Alzheimer's Research & Therapy 2010, 2:12 (14 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Amyloid beta has been identified as neurotoxic in patients with Alzheimer’s disease (AD), but we must take into account its structural characteristics, as well as size, when exploring AD development.
	Review Role of structural MRI in Alzheimer's disease Prashanthi Vemuri, Clifford R Jack Alzheimer's Research & Therapy 2010, 2:23 (31 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Structural MRI (sMRI) plays many roles as an Alzheimer’s disease (AD) biomarker and is of both prognostic and diagnostic value, but further work is needed in order to integrate it with other clinical measures.
	Research
	Research Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice? Philippe Robert, Steven Ferris, Serge Gauthier, Ralf Ihl, Bengt Winblad, Frank Tennigkeit Alzheimer's Research & Therapy 2010, 2:24 (26 August 2010) Abstract \| Full text \| PDF \| PubMed