Table 3

Summary of combined magnetic resonance imaging and Pittsburgh compound B studies in Alzheimer's disease

Study

Subjects

Associations

Archer et al., 2006 [70]

9 AD

Positive correlation between rates of whole-brain atrophy and regional PIB uptake

Jack et al., 2008 [69]

20 CN, 17 MCI, 8 AD

^aProportional odds to separate all groups: PIB: 0.75; MRI: 0.84; MRI + PIB: 0.86. Global PIB and MRI were correlated with each other as well as with clinical measures.

Jack et al., 2009 [1]

21 CN, 32 MCI, 8 AD

Longitudinal annual change was observed only in MRI and not in PIB. Change in MRI was associated with change in cognitive measures.

Mormino et al., 2009 [2]

37 CN, 39 PIB + MCI

PIB and MRI were correlated with each other as well as with episodic memory.

Scheinin et al., 2009 [71]

13 CN, 14 AD

During 2 years, only longitudinal MRI change was observed but not in PIB.

Strorandt et al., 2009 [66]

135 CN

PIB was associated with cross-sectional brain atrophy and longitudinal cognitive decline.

Bourgeat et al., 2010 [68]

92 CN, 32 MCI, 35 AD

In CN, PIB retention in the inferior temporal region and hippocampal volume were strongly correlated.

Chetalat et al., 2010 [67]

94 CN (49 subjective cognitive impairment), 34 MCI, 35 AD

Global atrophy and regional atrophy were strongly related to PIB load in CN subjects with subjective cognitive impairment but not MCI and AD.

Driscoll et al., 2010 [65]

57 CN

In CN, current PIB load was not related to longitudinal MRI changes in the preceding years.

Search terms were 'MRI and PIB and Alzheimer's'. ^aDiagnostic accuracy. AD, Alzheimer's disease; CN, cognitively normal; MCI, mild cognitive impairment; MRI, magnetic resonance imaging; PIB, Pittsburgh compound B.

Vemuri and Jack Alzheimer's Research & Therapy 2010 2:23   doi:10.1186/alzrt47