Alzheimer's Research & Therapy | Volume 2 Issue 5

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Articles

	Volume 2 Issue 5
	Comment
	Commentary Dimebon disappointment Roy W Jones Alzheimer's Research & Therapy 2010, 2:25 (13 September 2010) Abstract \| Full text \| PDF \| PubMed
	Commentary From model system to clinical medicine: pathophysiologic links of common proteinopathies Pamela J McMillan, James B Leverenz Alzheimers Res Ther 2010, 2:26 (17 September 2010) Abstract \| Full text \| PDF \| PubMed
	Commentary Obesity and the brain: a possible genetic link Lars Bertram, Hauke Heekeren Alzheimers Res Ther 2010, 2:27 (27 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bertram and Heekeren comment on a recent study showing that a reduction in regional brain volume correlates with specific alleles in the gene encoding the fat mass and obesity-associated protein and a novel genetic link between obesity and brain structure.
	Commentary Herbal therapy: a new pathway for the treatment of Alzheimer's disease Jinzhou Tian, Jing Shi, Xuekai Zhang, Yongyan Wang Alzheimer's Research & Therapy 2010, 2:30 (22 October 2010) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary On the basis of current evidence, Tian and colleagues discuss whether herbal therapy could be a novel pathway to treat Alzheimer’s disease (AD) and the implications of these results on future therapy development.
	Review
	Review Assessing the progression of mild cognitive impairment to Alzheimer's disease: current trends and future directions Larry G Brooks, David A Loewenstein Alzheimer's Research & Therapy 2010, 2:28 (29 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary From mild cognitive impairment through to dementia, Alzheimer’s disease is a continuous process and it is likely that multivariate models incorporating cognitive measures, functional variables and biomarker data are best suited to assess this longitudinal change.
	Review Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4 Daniel A Pollen, Stephen Baker, Douglas Hinerfeld, Joan Swearer, Barbara A Evans, James E Evans, Richard Caselli, Ekaterina Rogaeva, Peter St George-Hyslop, Majaz Moonis Alzheimer's Research & Therapy 2010, 2:31 (29 October 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Long-term statin therapy may reduce the risk of Alzheimer’s disease in high-risk, presymptomatic subjects, but further studies are necessary to evaluate this prophylactic effect in larger and longer-term trials.
	Research
	Research A Quick Test of cognitive speed is sensitive in detecting early treatment response in Alzheimer's disease Sebastian Palmqvist, Lennart Minthon, Carina Wattmo, Elisabet Londos, Oskar Hansson Alzheimer's Research & Therapy 2010, 2:29 (15 October 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A Quick Test of cognitive speed is twice as sensitive as the mini-mental state examination in evaluating cholinesterase inhibitor treatment in Alzheimer’s disease patients, indicating its potential usefulness in the primary care setting.