Alzheimer's Research & Therapy | Volume 2 Issue 6

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	Volume 2 Issue 6
	Review
	Review Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease Henrik Zetterberg, Niklas Mattsson, Kaj Blennow, Bob Olsson Alzheimer's Research & Therapy 2010, 2:32 (30 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Biomarkers which evaluate the intended biochemical effect of novel drugs for Alzheimer’s disease may help to select promising drugs for clinical trials, thereby cutting costs and accelerating drug development.
	Review Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials Joshua D Grill, Jason Karlawish Alzheimer's Research & Therapy 2010, 2:34 (21 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Clinical trialists in Alzheimer’s disease (AD) face many challenges and improving both enrolment and retention of patients are two key issues that need to be addressed to facilitate and hasten drug development.
	Report
	Meeting report A diverse portfolio of novel drug discovery efforts for Alzheimer's disease: Meeting report from the 11th International Conference on Alzheimer's Drug Discovery, 27-28 September 2010, Jersey City, NJ, USA Linda H Lee, Diana W Shineman, Howard M Fillit Alzheimer's Research & Therapy 2010, 2:33 (15 December 2010) Abstract \| Full text \| PDF \| PubMed
	Research
	Research Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Jeanne Baker, Robin Barbour, Michael Bova, Xiao-Hua Chen, Michael S Dappen, Tovah Eichenbaum, Erich Goldbach, Jon Hawkinson, Rose Lawler-Herbold, Kang Hu, Terence Hui, Jacek J Jagodzinski, Pamela S Keim, Dora Kholodenko, Lee H Latimer, Mike Lee, Jennifer Marugg, Matthew N Mattson, Scott McCauley, James L Miller, Ruth Motter, Linda Mutter, Martin L Neitzel, Huifang Ni, Lan Nguyen et al. Alzheimer's Research & Therapy 2010, 2:36 (29 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An amyloid precursor protein selective gamma-secretase inhibitor demonstrates selectivity for inhibiting Amyloid beta production in Alzheimer’s disease transgenic mice and needs to be corroborated in wild-type mice.