Alzheimer's Research & Therapy | Volume 3 Issue 1

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	Volume 3 Issue 1
	Comment
	Commentary What was lost in translation in the DHA trial is whom you should intend to treat Sally A Frautschy, Greg M Cole Alzheimer's Research & Therapy 2011, 3:2 (20 January 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease Randall J Bateman, Paul S Aisen, Bart De Strooper, Nick C Fox, Cynthia A Lemere, John M Ringman, Stephen Salloway, Reisa A Sperling, Manfred Windisch, Chengjie Xiong Alzheimer's Research & Therapy 2011, 3:1 (6 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Trials in autosomal-dominant Alzheimer’s disease (ADAD) are important in order for us to study individuals destined to develop the clinical disease and may yield breakthroughs in the treatment of sporadic AD.
	Review Amyloid imaging and memory change for prediction of cognitive impairment Susan M Resnick, Jitka Sojkova Alzheimer's Research & Therapy 2011, 3:3 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Should EOAD patients be included in clinical trials? Kinga Szigeti, Rachelle S Doody Alzheimer's Research & Therapy 2011, 3:4 (8 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Szigeti and Doody suggest that enrolling early-onset Alzheimer’s (EOAD) disease patients in clinical trials would help to detect a signal of efficacy, especially for amyloid-based therapies.
	Review Can aerobic exercise protect against dementia? Neill R Graff-Radford Alzheimer's Research & Therapy 2011, 3:6 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Aerobic exercise may be protective of brain health according to recent basic research and epidemiological studies, but prospective blinded studies are needed to evaluate its role in protecting against dementia.
	Research
	Research Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study Jonathan H Williams, Gordon K Wilcock, Jeffrey Seeburger, Aimee Dallob, Omar Laterza, William Potter, A David Smith Alzheimer's Research & Therapy 2011, 3:5 (17 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Levels of cerebrospinal fluid (CSF) beta amyloid and tau show non-linear relationships with cognitive scores, with more work necessary to be able to predict Alzheimer’s disease and monitor its progression.