Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
-
* Corresponding author: Randall J Bateman batemanr@wustl.edu
- † Equal contributors
1 Department of Neurology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8111, St Louis, MO 63110, USA
2 Department of Neurosciences, University of California San Diego, Gilman Drive, La Jolla, CA 92093, USA
3 Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
4 Center for Human Genetics, K.U. Leuven, Herestraat 49, 3000 Leuven, Belgium
5 Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
6 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
7 Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
8 Department of Neurology, Memory and Aging Program, Butler Hospital, 345 Blackstone Boulevard, Providence, Rhode Island 02906-4800, USA
9 Department of Clinical Neurosciences and Psychiatry, Brown Medical School, USA
10 Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
11 JSW LifeSciences GmbH, Parkring 12, A-8074 Grambach, Austria
12 Division of Biostatistics, Washington University, St Louis, MO 63110, USA
Alzheimer's Research & Therapy 2011, 3:1 doi:10.1186/alzrt59
Published: 6 January 2011Abstract
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.