Alzheimer's Research & Therapy | Volume 3 Issue 5

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	Volume 3 Issue 5
	Comment
	Commentary Amyloid imaging in prodromal Alzheimer's disease Rik Ossenkoppele, Bart NM van Berckel, Niels D Prins Alzheimer's Research & Therapy 2011, 3:26 (19 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ossenkoppele and colleagues discuss a new study demonstrating that, due to a gradual increase in amyloid deposition, amyloid imaging can predict clinical progression to Alzheimer's disease (AD) in patients with mild cognitive impairment.
	Commentary Defining and describing the pre-dementia stages of familial Alzheimer's disease Natalie S Ryan, Martin N Rossor Alzheimer's Research & Therapy 2011, 3:29 (27 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The need to establish a common framework for defining pre-dementia clinical stages of familial Alzheimer's disease (AD) is discussed by Ryan and Rosser, based on results from a recent study.
	Commentary Progress in understanding variability in cognitive responses to cholinesterase inhibitor treatment Valory N Pavlik, Rachelle S Doody Alzheimer's Research & Therapy 2011, 3:30 (17 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pavlik and Doody discuss findings in a recent study that older Alzheimer's disease (AD) patients and those with worse cognitive functioning had a better response to cholinesterase inhibitor treatment.
	Review
	Review Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies Diana W Shineman, Guriqbal S Basi, Jennifer L Bizon, Carol A Colton, Barry D Greenberg, Beth A Hollister, John Lincecum, Gabrielle G Leblanc, Linda (Bobbi) H Lee, Feng Luo, Dave Morgan, Iva Morse, Lorenzo M Refolo, David R Riddell, Kimberly Scearce-Levie, Patrick Sweeney, Juha Yrjänheikki, Howard M Fillit Alzheimer's Research & Therapy 2011, 3:28 (28 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shineman and colleagues review the contribution of animal models to the understanding of biological mechanisms in Alzheimer's disease (AD) and how the translation of these models to human clinical trials might be improved.
	Research
	Research Validation of the relevant outcome scale for Alzheimer's disease: a novel multidomain assessment for daily medical practice Vjera A Holthoff, Steven Ferris, Ralf Ihl, Philippe Robert, Bengt Winblad, Serge Gauthier, Kati Sternberg, Frank Tennigkeit Alzheimer's Research & Therapy 2011, 3:27 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Relevant Outcome Scale for Alzheimer's disease (ROSA) is a valid and reliable instrument to aid medical practitioners in the routine assessment of the severity of Alzheimer's disease symptoms and disease progression.