Beyond amyloid: a diverse portfolio of novel drug discovery programs for Alzheimer's disease and related dementias
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* Corresponding author: Howard M Fillit HFillit@alzdiscovery.org
Alzheimer's Drug Discovery Foundation, 57 W57th Street, Suite 904, New York, NY 10014, USA
Alzheimer's Research & Therapy 2011, 3:36 doi:10.1186/alzrt99
Published: 20 December 2011Abstract
Although the molecular mechanisms underlying the pathogenesis of Alzheimer's disease and other related neurodegenerative diseases remain unclear, accumulation of misfolded proteins, neuroinflammation, mitochondrial dysfunction and perturbed calcium homeostasis have been identified as key events leading to neuronal loss during neurodegeneration. Evidence for 'druggable' targets for each of these key mechanisms was presented by the Alzheimer's Drug Discovery Foundation-funded investigators at the 12th International Conference on Alzheimer's Drug Discovery, Jersey City, NJ, 26-27 September 2011 http://www.worldeventsforum.com/addf/addrugdiscovery webcite.