Alzheimer's Research & Therapy | Volume 4 Issue 1

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	Volume 4 Issue 1
	Comment
	Commentary Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design Benjamin Wolozin Alzheimer's Research & Therapy 2011, 4:3 (16 January 2012) Abstract \| Full text \| PDF
	Review
	Review Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review Helena C Chui, Ling Zheng, Bruce R Reed, Harry V Vinters, Wendy J Mack Alzheimer's Research & Therapy 2011, 4:1 (4 January 2012) Abstract \| Full text \| PDF \| Editor’s summary Current studies fail to show a positive association between vascular risk factors and an increase in Alzheimer's disease (AD) pathology, as discussed in an evidence-based review by Chui and colleagues.
	Review Resting state functional MRI in Alzheimer's Disease Prashanthi Vemuri, David T Jones, Clifford R Jack Alzheimer's Research & Therapy 2011, 4:2 (10 January 2012) Abstract \| Full text \| PDF \| Editor’s summary Vemuri and colleagues discuss the use of resting-state functional magnetic resonance imaging (fMRI) as an emerging Alzheimer's disease biomarker and consider future developments and open questions in the field.
	Review Progranulin axis and recent developments in frontotemporal lobar degeneration Alexandra M Nicholson, Jennifer Gass, Leonard Petrucelli, Rosa Rademakers Alzheimer's Research & Therapy 2012, 4:4 (23 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent data involving progranulin protein (PGRN) biology and frontotemporal lobar degeneration (FTLD), and the necessity of further elucidation of PGRN biology in FTLD-related neurodegeneration, is discussed by Nicholson and colleagues.
	Review Lipidomics of Alzheimer's disease: current status Paul L Wood Alzheimer's Research & Therapy 2012, 4:5 (1 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Current applications of lipidomic technologies and the potential roles of lipid deficits and alterations in the pathophysiology of Alzheimer's disease (AD) are discussed by Wood.
	Review Dementia prevention: current epidemiological evidence and future perspective Francesca Mangialasche, Miia Kivipelto, Alina Solomon, Laura Fratiglioni Alzheimer's Research & Therapy 2012, 4:6 (13 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mangialasche and colleagues address current epidemiological research and intervention studies to identify promising preventative strategies for Alzheimer's disease (AD) and dementia; considering the need for randomized controlled trials to confirm these findings.