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Highly Accessed Review

Resting state functional MRI in Alzheimer's Disease

Prashanthi Vemuri1*, David T Jones2 and Clifford R Jack1

Author Affiliations

1 Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA

2 Department of Neurology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA

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Alzheimer's Research & Therapy 2011, 4:2  doi:10.1186/alzrt100


See related commentary by Damoiseaux, http://alzres.com/content/4/2/8

Published: 10 January 2012

Abstract

Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss the origins of resting-state fMRI, common methodologies used to extract information from these four-dimensional fMRI scans, and important considerations for the analysis of these scans. Then we present the current state of knowledge in this area by summarizing various AD resting-state fMRI studies presented in the first section and end with a discussion of future developments and open questions in the field.