Alzheimer's Research & Therapy | Volume 4 Issue 2

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	Volume 4 Issue 2
	Comment
	Commentary Resting-state fMRI as a biomarker for Alzheimer's disease? Jessica S Damoiseaux Alzheimer's Research & Therapy 2012, 4:8 (15 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Damoiseaux comments on a recent review discussing resting-state functional magnetic resonance imaging (fMRI) in the study of Alzheimer's disease, considering key aspects surrounding its biomarker potential.
	Review
	Review Cognitive reserve, cortical plasticity and resistance to Alzheimer's disease Margaret M Esiri, Steven A Chance Alzheimer's Research & Therapy 2012, 4:7 (1 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Esiri and Chance discuss the impact of epidemiological factors on cognitive reserve and cortical plasticity, which act as preventative factors against cognitive decline and the development of Alzheimer's disease (AD) in the elderly.
	Review Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease Sascha Weggen, Dirk Beher Alzheimer's Research & Therapy 2012, 4:9 (30 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The molecular consequences of amyloid precursor protein and presenilin gene mutations in familial Alzheimer's disease (FAD) are examined by Weggen and Beher; in view of potential therapeutic treatments directed at amyloid-beta peptides.
	Review Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems Sally Hunter, Carol Brayne Alzheimer's Research & Therapy 2012, 4:10 (13 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hunter and Brayne build a map, modelling relationships between the amyloid precursor protein (APP) and its proteolytic fragments with other neuronal systems and discussing alternative perspectives for its role in Alzheimer's disease progression.
	Review Examining the mechanisms that link β-amyloid and α-synuclein pathologies Samuel E Marsh, Mathew Blurton-Jones Alzheimer's Research & Therapy 2012, 4:11 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marsh and Blurton-Jones review evidence suggesting β-amyloid (Aβ) and α-synuclein (α-syn) interact synergistically to enhance aggregation and accelerate cognitive decline, and propose potential mechanistic links between Aβ and α-syn pathologies.
	Research
	Research Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice Guilian Xu, Cameron C Green, Susan E Fromholt, David R Borchelt Alzheimer's Research & Therapy 2012, 4:12 (26 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reduction in levels of low-density lipoprotein receptor-related protein (LRP1) in an in vivo mouse model failed to observe a reduction in amyloidosis, questioning its significance as a potential therapeutic target for Alzheimer's disease.