Alzheimer's Research & Therapy | Volume 4 Issue 4

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	Volume 4 Issue 4
	Comment
	Debate Pro: Alzheimer's disease and circadian dysfunction: chicken or egg? Tracy A Bedrosian, Randy J Nelson Alzheimer's Research & Therapy 2012, 4:25 (13 August 2012) Abstract \| Full text \| PDF \| PubMed
	Debate Con: Alzheimer's disease and circadian dysfunction: chicken or egg? Abhay Moghekar, Richard J O'Brien Alzheimer's Research & Therapy 2012, 4:26 (13 August 2012) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Supporting clinical research in the NHS in England: the National Institute for Health Research Dementias and Neurodegenerative Diseases Research Network Piers Kotting, Kris Beicher, Ian G McKeith, Martin N Rossor Alzheimer's Research & Therapy 2012, 4:23 (6 July 2012) Abstract \| Full text \| PDF \| PubMed
	Review Measuring clinical progression in MCI and pre-MCI populations: enrichment and optimizing clinical outcomes over time Suzanne B Hendrix Alzheimer's Research & Therapy 2012, 4:24 (13 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Suzanne Hendrix reviews the importance of clinical outcomes for validating biomarkers and improving the identification of patients with very early stages of Alzheimer's disease (AD), discussing current neuropsychological tests.
	Review Genetic counseling for FTD/ALS caused by the C9ORF72 hexanucleotide expansion Jamie C Fong, Anna M Karydas, Jill S Goldman Alzheimer's Research & Therapy 2012, 4:27 (19 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fong and colleagues discuss the genetic counselling considerations for individuals and their families considering genetic testing for the pathogenic C9ORF72 hexanucleotide expansion in familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
	Review Cognitive and behavioral features of c9FTD/ALS Bradley F Boeve, Neill R Graff-Radford Alzheimer's Research & Therapy 2012, 4:29 (20 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Boeve and Graff-Radford review the major new findings in familial frontotemporal dementia and/or amyotrophic lateral sclerosis linked to chromosome 9 (c9FTD/ALS) and its recently discovered pathogenic C9ORF72 hexanucleotide expansion.
	Review Expanding the genetics of amyotrophic lateral sclerosis and frontotemporal dementia Jennifer C Schymick, Bryan J Traynor Alzheimer's Research & Therapy 2012, 4:30 (26 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease Adam Kline Alzheimer's Research & Therapy 2012, 4:32 (27 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adam Kline discusses therapeutic approaches targeting apolipoprotein E (apoE), the most significant risk factor for non-familial Alzheimer's disease (AD), including key interactions of apoE and amyloid-beta pathology and preclinical animal models.
	Research
	Research Systematic reviews on behavioural and psychological symptoms in the older or demented population Rianne M van der Linde, Blossom CM Stephan, George M Savva, Tom Dening, Carol Brayne Alzheimer's Research & Therapy 2012, 4:28 (11 July 2012) Abstract \| Full text \| PDF \| PubMed
	Research Increased expression of the homologue of enhancer-of-split 1 protects neurons from beta amyloid neurotoxicity and hints at an alternative role for transforming growth factor beta1 as a neuroprotector Pedro J Chacón, Alfredo Rodríguez-Tébar Alzheimer's Research & Therapy 2012, 4:31 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Up-regulating the gene Hes1 largely counteracted the effects of amyloid beta (Aβ) on neurons, maintaining GABAergic signaling and preventing cell death; providing strategies for limiting the effects of Alzheimer's disease.
	Research Dystrophic neurites express C9orf72 in Alzheimer's disease brains Jun-ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arima Alzheimer's Research & Therapy 2012, 4:33 (16 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary C9orf72 and UBQLN-1 expression in a cluster of dystrophic neurites in senile plaques in Alzheimer's disease brains suggests C9orf72 has a role in the process of neurodegeneration.
	Research Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort Sheng Jin, Pau Pastor, Breanna Cooper, Sebastian Cervantes, Bruno A Benitez, Cristina Razquin, Alison Goate, Ibero-American Alzheimer Disease Genetics Group Researchers, Carlos Cruchaga Alzheimer's Research & Therapy 2012, 4:34 (20 August 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Pooled-DNA sequencing identifies novel GRN and MAPT mutations that match the frequency of APP, PSEN1 and PSEN2 mutations in clinical Alzheimer's disease (AD) cases, suggesting an influence on frontotemporal dementia and AD phenotypes.