Review

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

Amanda N Sacino and Benoit I Giasson

Alzheimer's Research & Therapy 2012, 4:48 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Sacino and Giasson review evidence that a self-promoting prion-like mechanism may contribute to the spread and progression of alpha-synuclein pathology in Parkinson’s disease and other synucleinopathies, calling for further study.

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