Plasma tau levels in Alzheimer's disease
1 Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden
2 UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
3 Quanterix Corporation, 113 Hartwell Avenue, Lexington, MA 02421, USA
4 Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Simrisbanvägen 14, S-212 24 Malmö, Sweden
Alzheimer's Research & Therapy 2013, 5:9 doi:10.1186/alzrt163Published: 28 March 2013
First paragraph (this article has no abstract)
Efforts to find reliable blood biomarkers for Alzheimer's disease (AD) in a highly warranted clinical laboratory test have met with little success. There is no clear change in plasma β-amyloid in AD, and assays for the axonal injury marker tau have been hampered by a lack of analytical sensitivity for accurate measurement in blood samples . Here, the results of a novel ultra-sensitive assay for tau in peripheral blood are reported.