Review

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

Andrew B Wolf , Jon Valla , Guojun Bu , Jungsu Kim , Mary Jo LaDu , Eric M Reiman and Richard J Caselli

Alzheimer's Research & Therapy 2013, 5:38 (3 September 2013)

Caselli and colleagues review the emerging roles of apolipoprotein E in the Alzheimer’s disease process that are independent of β-amyloid, including lipid metabolism, tau processing, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation.

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